7-Nitro-1H-indole-2-carboxylic Acid

• CAT Number: R060587
• CAS Number: 6960-45-8
• Molecular Formula: C9H6N2O4
• Molecular Weight: 206.157
• Purity: ≥95%
• Synonyms: 7-Nitro-indole-2-carboxylic Acid; 7-Nitro-2-indolecarboxylic Acid; 7-Nitroindol-2-carboxylic Acid; CRT 0044876; NSC 69877
• Target: DNA/RNA Synthesis
• Solubility: >8.35mg/mL in DMSO
• Storage: Store at -20 C
• InChI: InChI=1S/C9H6N2O4/c12-9(13)6-4-5-2-1-3-7(11(14)15)8(5)10-6/h1-4,10H,(H,12,13)
• InChIKey: BIUCOFQROHIAEO-UHFFFAOYSA-N
• SMILES: C1=CC2=C(C(=C1)[N+](=O)[O-])NC(=C2)C(=O)O

CRT0044876 is a potent BER inhibitor or DNA Base Excision Repair Pathway Inhibitor (APE1 IC50 – 3 microM). CRT0044876 potentiates the cytotoxicity of several DNA base-targeting compounds, with accumulation of apurinic sites.

Reference

1:Design, synthesis and biological evaluation of 7-nitro-1H-indole-2-carboxylic acid derivatives as allosteric inhibitors of fructose-1,6-bisphosphatase. Bie J, Liu S, Zhou J, Xu B, Shen Z.Bioorg Med Chem. 2014 Mar 15;22(6):1850-62. doi: 10.1016/j.bmc.2014.01.047. Epub 2014 Feb 2. PMID: 24530031 2:Cellular inhibition of checkpoint kinase 2 (Chk2) and potentiation of camptothecins and radiation by the novel Chk2 inhibitor PV1019 [7-nitro-1H-indole-2-carboxylic acid {4-[1-(guanidinohydrazone)-ethyl]-phenyl}-amide]. Jobson AG, Lountos GT, Lorenzi PL, Llamas J, Connelly J, Cerna D, Tropea JE, Onda A, Zoppoli G, Kondapaka S, Zhang G, Caplen NJ, Cardellina JH 2nd, Yoo SS, Monks A, Self C, Waugh DS, Shoemaker RH, Pommier Y.J Pharmacol Exp Ther. 2009 Dec;331(3):816-26. doi: 10.1124/jpet.109.154997. Epub 2009 Sep 9. PMID: 19741151 Free PMC Article