For research use only. Not for therapeutic Use.
7,3′,4′-Trihydroxyisoflavone, a major metabolite of Daidzein, is an ATP-competitive inhibitor of Cot (Tpl2/MAP3K8) and MKK4. 7,3′,4′-Trihydroxyisoflavone has anticancer, anti-angiogenic, chemoprotective, and free radical scavenging activities[1][2].
7,3′,4′-Trihydroxyisoflavone triggers cell cycle arrest at the G1 phase and displays an anti-proliferative effect against EGF receptor-positive skin cancer[1].
7,3′,4′-Trihydroxyisoflavone also significantly inhibits UVB-induced COX-2 expression by suppressing the NF-B transcription activity in mouse skin epidermal JB6 P+ cells[1].
In a mouse skin tumorigenesis model, 7,3′,4′-Trihydroxyisoflavone strongly suppresses the incidence, multiplicity, and volume of UVB-induced mouse skin tumors. Consistent with the tumor data, 7,3′,4′-Trihydroxyisoflavone clearly attenuates UVB-induced COX-2 expression in hairless mouse skin[2].
| Catalog Number | R000625 |
| CAS Number | 485-63-2 |
| Synonyms | 3-(3,4-dihydroxyphenyl)-7-hydroxychromen-4-one |
| Molecular Formula | C15H10O5 |
| Purity | ≥95% |
| InChI | InChI=1S/C15H10O5/c16-9-2-3-10-14(6-9)20-7-11(15(10)19)8-1-4-12(17)13(18)5-8/h1-7,16-18H |
| InChIKey | DDKGKOOLFLYZDL-UHFFFAOYSA-N |
| SMILES | C1=CC(=C(C=C1C2=COC3=C(C2=O)C=CC(=C3)O)O)O |
| Reference | [1]. Yu-Li Lo, et al. 7,3′,4′-Trihydroxyisoflavone modulates multidrug resistance transporters and induces apoptosis via production of reactive oxygen species. Toxicology. 2012 Dec 16;302(2-3):221-32. [2]. Dong Eun Lee, et al. 7,3′,4′-Trihydroxyisoflavone, a metabolite of the soy isoflavone daidzein, suppresses ultraviolet B-induced skin cancer by targeting Cot and MKK4. J Biol Chem. 2011 Apr 22;286(16):14246-56. |
