For research use only. Not for therapeutic Use.
7,4′-Dihydroxyflavone (7,4′-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4′-Dihydroxyflavone is eotaxin/CCL11 inhibitor and CBR1 inhibitor (IC50=0.28 μM). 7,4′-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production[1]. 7,4′-Dihydroxyflavone (7,4′-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4′-Dihydroxyflavone (7,4′-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC50 value of 1.4 µM[1].
7,4′-Dihydroxyflavone (10 μM, 72-120 h) inhibits constitutive eotaxin production in HFL-1 cells[1].
7,4′-Dihydroxyflavone (10 μM, 72 h) decreases IL-4/TNF-α stimulated p-STAT6, p-IκBα, and p-Akt expression in HFL-1 cells[1].
7,4′-Dihydroxyflavone (10 μM, 30 min) inhibits Phorbol 12-myristate 13-acetate (HY-18739) (10 ng/mL for 24 h)-induced MUC5AC production and gene expression in NCI-H292 cells[2].
7,4′-Dihydroxyflavone (6 µg, oral gavage, 4 weeks) inhibits bronchoalveolar lavage (BAL) MUC5AC secretion in a murine asthma model[2].
| Catalog Number | R015683 |
| CAS Number | 2196-14-7 |
| Synonyms | 7-hydroxy-2-(4-hydroxyphenyl)chromen-4-one |
| Molecular Formula | C15H10O4 |
| Purity | ≥95% |
| InChI | InChI=1S/C15H10O4/c16-10-3-1-9(2-4-10)14-8-13(18)12-6-5-11(17)7-15(12)19-14/h1-8,16-17H |
| InChIKey | LCAWNFIFMLXZPQ-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC=C1C2=CC(=O)C3=C(O2)C=C(C=C3)O)O |
| Reference | [1]. Liu C, et al. The Flavonoid 7,4′-Dihydroxyflavone Prevents Dexamethasone Paradoxical Adverse Effect on Eotaxin Production by Human Fibroblasts. Phytother Res. 2017 Mar;31(3):449-458. [2]. Arai Y, et al. Structure-activity relationship of flavonoids as potent inhibitors of carbonyl reductase 1 (CBR1). Fitoterapia. 2015 Mar;101:51-6. |
