7,7’-[(1,4-Butanediyl)bis(oxy)]bis-2(1H)quinolinone

• CAT Number: C000074
• CAS Number: 2116542-19-7
• Molecular Formula: C₂₂H₂₀N₂O₄
• Molecular Weight: 376.41
• Purity: ≥95%
• Synonyms: 7-[4-[(2-Oxo-1H-quinolin-7-yl)oxy]butoxy]-1H-quinolin-2-one; Brexpiprazole Impurity-12
• Solubility: DMSO (Slightly, Heated, Sonicated)
• Appearance: Off-White to Pale Yellow Solid
• Storage: 4°C

7,7’-[(1,4-Butanediyl)bis(oxy)]bis-2(1H)quinolinone (CAT: C000074) is an impurity that can be found in the production of Brexpiprazole, a drug candidate used in the treatment and prevention of mental disorders, including central nervous system (CNS) disorders. Impurities like 7,7’-[(1,4-Butanediyl)bis(oxy)]bis-2(1H)quinolinone are closely monitored and controlled during pharmaceutical manufacturing to ensure the purity, safety, and efficacy of the final drug product.

Reference

Yamashita, H., et al.: PCT Int. Appl., WO 2006112464 A1 20061026 (2006)