7ACC1

• CAT Number: I003819
• CAS Number: 50995-74-9
• Molecular Formula: C14H15NO4
• Molecular Weight: 261.27
• Purity: ≥95%
• Synonyms: 7-(diethylamino)-2-oxochromene-3-carboxylic acid
• Target: Monocarboxylate Transporter
• Solubility: DMSO 32 mg/ml
• Storage: Room temperature
• IC50: 0.86 uM(Lactate uptake inhibition)
• InChI: InChI=1S/C14H15NO4/c1-3-15(4-2)10-6-5-9-7-11(13(16)17)14(18)19-12(9)8-10/h5-8H,3-4H2,1-2H3,(H,16,17)
• InChIKey: WHCPTFFIERCDSB-UHFFFAOYSA-N
• SMILES: CCN(CC)C1=CC2=C(C=C1)C=C(C(=O)O2)C(=O)O

7ACC1 is a compound with the ability to selectively disrupt lactate flux in the tumor microenvironment. It exerts its action by inhibiting the uptake of lactate in tumor cells that express MCT1 and MCT4 transporters, effectively blocking lactate influx. However, it does not impact the release of lactate from these cells, allowing the accumulation of lactate in the tumor microenvironment. This unique mechanism makes 7ACC1 a potential candidate for altering the metabolic dynamics within tumors, which is an area of active research for its potential in cancer therapy and modulation of the tumor microenvironment. If you need to, please contact us in time, and we will reply to you as soon as possible within 24 hours.

Reference

[1]. Draoui N, et al. Antitumor activity of 7-aminocarboxycoumarin derivatives, a new class of potent inhibitors of lactate influx but not efflux. Mol Cancer Ther. 2014 Jun;13(6):1410-8.