7ACC2

• CAT Number: I001797
• CAS Number: 1472624-85-3
• Molecular Formula: C18H15NO4
• Molecular Weight: 309.32
• Purity: ≥95%
• Synonyms: [(1aS,2S,7aS)-1a,2,7,7a-tetrahydro-1H-cyclopropa[b]naphthalen-2-yl] 4-nitrobenzoate
• Target: MCT
• Solubility: DMSO 46 mg/ml
• Storage: Store at -20°C
• IC50: 11 nM ([14C]-lactate influx)
• IUPAC Name: 7-[benzyl(methyl)amino]-2-oxochromene-3-carboxylic acid
• InChI: InChI=1S/C18H15NO4/c1-19(11-12-5-3-2-4-6-12)14-8-7-13-9-15(17(20)21)18(22)23-16(13)10-14/h2-10H,11H2,1H3,(H,20,21)
• InChIKey: XTKDQPFUOFAMRL-UHFFFAOYSA-N
• SMILES: O=C1C(C(O)=O)=CC2=CC=C(N(CC3=CC=CC=C3)C)C=C2O1

7ACC2 (CAT: I001797) is a potent and selective inhibitor of the monocarboxylate transporter 2 (MCT2). MCT2 is a transporter protein involved in the cellular uptake of lactate, an important metabolite in energy metabolism. By inhibiting MCT2, 7ACC2 disrupts lactate transport and impairs the ability of cancer cells to utilize lactate for energy production. This leads to metabolic stress and can potentially inhibit tumor growth. 7ACC2 has shown efficacy in preclinical studies as a potential anticancer agent, particularly in tumors that rely heavily on lactate metabolism. Further research is ongoing to explore its therapeutic applications and optimize its clinical potential.

Reference

[1]. Draoui N, et al. Synthesis and pharmacological evaluation of carboxycoumarins as a new antitumor treatment targeting lactate transport in cancer cells. Bioorg Med Chem. 2013 Nov 15;21(22):7107-17.