For research use only. Not for therapeutic Use.
7ß,27-Dihydroxycholesterol (7β, 27-OHC) is a potent and selective activator of RORγt (Ki=120 nM). 7ß,27-Dihydroxycholesterol promotes the differentiation of mouse and human CD4+ Th17 cells. 7ß,27-Dihydroxycholesterol also increases the production of IL-17 depended on CYP27A1[1].
7ß,27-Dihydroxycholesterol (0.3 μM or 6 μM; 2 h) induces IL-17 production in human and mouse Th17 cells, respectively, in vitro[1].
7ß,27-Dihydroxycholesterol (60 mg/kg; s.c.; twice daily for 3 d) induces IL-17 production in mice in vivo[1].
| Catalog Number | I041790 |
| CAS Number | 240129-43-5 |
| Synonyms | (3S,7R,8S,9S,10R,13R,14S,17R)-17-[(2R,6R)-7-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol |
| Molecular Formula | C27H46O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h15,17-18,20-25,28-30H,5-14,16H2,1-4H3/t17-,18-,20+,21-,22+,23+,24+,25+,26+,27-/m1/s1 |
| InChIKey | RXMHNAKZMGJANZ-BMOLSTJGSA-N |
| SMILES | CC(CCCC(C)C1CCC2C1(CCC3C2C(C=C4C3(CCC(C4)O)C)O)C)CO |
| Reference | [1]. Soroosh P, et al. Oxysterols are agonist ligands of RORγt and drive Th17 cell differentiation. Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12163-8. |
