For research use only. Not for therapeutic Use.
1,8-<wbr></wbr>ANS is a fluorescent dye that binds with high affinity to hydrophobic surfaces of proteins. The emission maximum of 1,8-<wbr></wbr>ANS undergoes a blue shift and fluorescence intensity increases significantly upon binding to low polarity regions of a protein surface. These properties make 1,8-<wbr></wbr>ANS well suited for determining the affinity of hydrophobic ligands to their corresponding binding proteins, such as the binding of free fatty acids to fatty acid binding proteins (FABPs). 1,8-<wbr></wbr>ANS binds to intestinal FABP (FABP2) with a K<sub>d</sub> value of ~9.7 µM at 24.5°C.
Catalog Number | R064352 |
CAS Number | 82-76-8 |
Synonyms | 1-(Phenylamino)-8-naphthalenesulfonic Acid; 1-Anilino-8-naphthalenesulfonic Acid; 8-(Phenylamino)-1-naphthalenesulfonic Acid; 8-Anilino-1-naphthalenesulfonate; ANS;?ANS (Fluorescent Probe); NSC 1746; Phenyl Peri Acid |
Molecular Formula | C16H13NO3S |
Purity | ≥95% |
Storage | -20°C |
IUPAC Name | 8-anilinonaphthalene-1-sulfonic acid |
InChI | InChI=1S/C16H13NO3S/c18-21(19,20)15-11-5-7-12-6-4-10-14(16(12)15)17-13-8-2-1-3-9-13/h1-11,17H,(H,18,19,20) |
InChIKey | FWEOQOXTVHGIFQ-UHFFFAOYSA-N |
SMILES | C1=CC=C(C=C1)NC2=CC=CC3=C2C(=CC=C3)S(=O)(=O)O |