8-Bromo-2'-deoxyadenosine

• CAT Number: R041612
• CAS Number: 14985-44-5
• Molecular Formula: C10H12BrN5O3
• Molecular Weight: 330.14
• Purity: ≥95%
• Synonyms: (2R,5R)-5-(6-amino-8-bromopurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol
• IUPAC Name: (2R,3S,5R)-5-(6-amino-8-bromopurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol
• InChI: InChI=1S/C10H12BrN5O3/c11-10-15-7-8(12)13-3-14-9(7)16(10)6-1-4(18)5(2-17)19-6/h3-6,17-18H,1-2H2,(H2,12,13,14)/t4-,5+,6+/m0/s1
• InChIKey: NJBIVXMQFIQOGE-KVQBGUIXSA-N
• SMILES: C1[C@@H]([C@H](O[C@H]1N2C3=NC=NC(=C3N=C2Br)N)CO)O

8-Bromo-2′-deoxyadenosine（Cat No.:R041612）is a nucleoside analogue of deoxyadenosine, where a bromine atom replaces the 8-hydrogen of the adenine base. This modification can disrupt normal DNA replication and transcription by inducing DNA damage or altering base pairing. It is often used as a research tool to study DNA repair mechanisms, mutagenesis, and the effects of oxidative stress on cellular processes. 8-Bromo-2′-deoxyadenosine has potential applications in cancer research due to its ability to interfere with DNA synthesis in rapidly dividing cells, leading to cell death or growth inhibition.