8-Bromo-2’-deoxyguanosine

• CAT Number: R001907
• CAS Number: 13389-03-2
• Molecular Formula: C₁₀H₁₂BrN₅O₄
• Molecular Weight: 346.14
• Purity: ≥95%
• Synonyms: 8-Bromo-2’-deoxy-guanosine; 8-Bromo-2’-deoxyguanosine; NSC 105830
• Target: Nucleoside Antimetabolite/Analog
• Storage: -20°C
• IUPAC Name: 2-amino-8-bromo-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-purin-6-one
• InChI: InChI=1S/C10H12BrN5O4/c11-9-13-6-7(14-10(12)15-8(6)19)16(9)5-1-3(18)4(2-17)20-5/h3-5,17-18H,1-2H2,(H3,12,14,15,19)/t3-,4+,5+/m0/s1
• InChIKey: MKDXZFVCXWXGBQ-VPENINKCSA-N
• SMILES: C1[C@@H]([C@H](O[C@H]1N2C3=C(C(=O)NC(=N3)N)N=C2Br)CO)O

8-Bromo-2’-deoxyguanosine（Cat No.:R001907）is a modified nucleoside where a bromine atom is substituted at the 8-position of the guanine base. This compound is widely used in biochemical research to study DNA damage, mutagenesis, and nucleotide interactions, as it mimics oxidative stress-induced DNA lesions. Its incorporation into DNA can result in altered base pairing and replication errors, making it useful for investigating mechanisms of DNA repair and stability. 8-Bromo-2’-deoxyguanosine is also valuable in cancer research and drug development, where DNA damage and repair processes are key therapeutic targets.