For research use only. Not for therapeutic Use.
8-Bromo-AMP (8-Bromoadenosine 5′-monophosphate) is a membrane permeable cAMP analogue. 8-Bromo-AMP can improve the ability of the heart to recover from ischemia and reperfusion by increasing the levels of ATP, ADP, and total adenine nucleotides[1][2].
| Catalog Number | I045345 |
| CAS Number | 23567-96-6 |
| Synonyms | [(2R,3S,4R,5R)-5-(6-amino-8-bromopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate |
| Molecular Formula | C10H13BrN5O7P |
| Purity | ≥95% |
| InChI | InChI=1S/C10H13BrN5O7P/c11-10-15-4-7(12)13-2-14-8(4)16(10)9-6(18)5(17)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,17-18H,1H2,(H2,12,13,14)(H2,19,20,21)/t3-,5-,6-,9-/m1/s1 |
| InChIKey | DNPIJKNXFSPNNY-UUOKFMHZSA-N |
| SMILES | C1=NC(=C2C(=N1)N(C(=N2)Br)C3C(C(C(O3)COP(=O)(O)O)O)O)N |
| Reference | [1]. Jiang J, et, al. Evidences for involvement of endogenous cAMP in Arabidopsis defense responses to Verticillium toxins. Cell Res. 2005 Aug;15(8):585-92. [2]. Nakai T, et, al. Effects of adenine nucleotide analogues on myocardial dysfunction during reperfusion after ischemia in dogs. J Cardiovasc Pharmacol. 1996 Aug;28(2):264-70. |
