8-Bromo-cAMP, sodium salt

• CAT Number: I010375
• CAS Number: 76939-46-3
• Molecular Formula: C10H10BrN5O6P • Na
• Molecular Weight: 430.10
• Purity: ≥95%
• Synonyms: 8-Bromoadenosine-3′,5′-cyclic monophosphate sodium salt
• Target: TGF-beta/Smad
• Solubility: Soluble to 100 mM in water
• Storage: Desiccate at -20°C
• IUPAC Name: sodium;(4aR,6R,7R,7aS)-6-(6-amino-8-bromopurin-9-yl)-2-oxido-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol
• InChI: 1S/C10H11BrN5O6P.Na/c11-10-15-4-7(12)13-2-14-8(4)16(10)9-5(17)6-3(21-9)1-20-23(18,19)22-6;/h2-3,5-6,9,17H,1H2,(H,18,19)(H2,12,13,14);/q;+1/p-1/t3-,5-,6-,9-;/m1./s1
• InChIKey: DMRMZQATXPQOTP-GWTDSMLYSA-M
• SMILES: O[C@H]1[C@H](N2C(Br)=NC3=C2N=CN=C3N)O[C@H]4[C@H]1OP(OC4)([O-])=O.[Na+]

8-Bromo-cAMP, sodium salt (CAT: I010375) is a cell-permeable analog of cyclic adenosine monophosphate (cAMP). It serves as an activator of protein kinase A (PKA), a key enzyme involved in various cellular signaling pathways. By mimicking the action of endogenous cAMP, 8-Bromo-cAMP can penetrate the cell membrane and stimulate PKA activity. This activation of PKA can lead to downstream effects such as the phosphorylation of target proteins and subsequent modulation of cellular processes.