For research use only. Not for therapeutic Use.
8-Bromoguanosine is a brominated derivative of guanosine. Purine nucleobases with bromine at position eight are known to preferentially adopt the <em>syn</em> conformation as nucleosides and, thus, can be used to reduce the conformational heterogeneity of RNA to potentially enhance its function. It is reported to activate lymphocytes through an intracellular mechanism to exert immunostimulatory effects.
| Catalog Number | R001245 |
| CAS Number | 4016-63-1 |
| Synonyms | 2-Amino-8-bromo-6-hydroxypurine Riboside; NSC 174257; NSC 79211; |
| Molecular Formula | C10H12BrN5O5 |
| Purity | ≥95% |
| Storage | -20°C |
| IUPAC Name | 2-amino-8-bromo-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one |
| InChI | InChI=1S/C10H12BrN5O5/c11-9-13-3-6(14-10(12)15-7(3)20)16(9)8-5(19)4(18)2(1-17)21-8/h2,4-5,8,17-19H,1H2,(H3,12,14,15,20)/t2-,4-,5-,8-/m1/s1 |
| InChIKey | ASUCSHXLTWZYBA-UMMCILCDSA-N |
| SMILES | C(C1C(C(C(O1)N2C3=C(C(=O)N=C(N3)N)N=C2Br)O)O)O |
