8-Geranyloxypsoralen

• CAT Number: R003099
• CAS Number: 7437-55-0
• Molecular Formula: C21H22O4
• Molecular Weight: 338.40
• Purity: ≥95%
• Synonyms: 9-[(2E)-3,7-dimethylocta-2,6-dienoxy]furo[3,2-g]chromen-7-one
• InChI: InChI=1S/C21H22O4/c1-14(2)5-4-6-15(3)9-11-24-21-19-17(10-12-23-19)13-16-7-8-18(22)25-20(16)21/h5,7-10,12-13H,4,6,11H2,1-3H3/b15-9+
• InChIKey: SOVNCTNQAWWYAQ-OQLLNIDSSA-N
• SMILES: CC(=CCCC(=CCOC1=C2C(=CC3=C1OC=C3)C=CC(=O)O2)C)C

8-Geranyloxypsoralen is a furanocoumarin isolated from grapefruit, acts as a potent inhibitor of P450 3A4 (CYP3A4) with an IC50 of 3.93 μM[1].

Reference

[1]. Row EC, et al. Synthesis of 8-geranyloxypsoralen analogues and their evaluation as inhibitors of CYP3A4. Bioorg Med Chem. 2006 Jun 1;14(11):3865-71.
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