8-Hydroxy Guanosine

• CAT Number: R000939
• CAS Number: 3868-31-3
• Molecular Formula: C10H13N5O6
• Molecular Weight: 299.243
• Purity: ≥95%
• Synonyms: 2-Amino-9-β-D-ribofuranosyl-purine-6,8(1H,9H)-dione;?8-OHG; 8-Oxo-7,8-dihydroguanosine; 8-Oxoguanosine; NSC 90393
• Target: Endogenous Metabolite
• Storage: Room temperature
• IUPAC Name: 2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3,7-dihydropurine-6,8-dione
• InChI: InChI=1S/C10H13N5O6/c11-9-13-6-3(7(19)14-9)12-10(20)15(6)8-5(18)4(17)2(1-16)21-8/h2,4-5,8,16-18H,1H2,(H,12,20)(H3,11,13,14,19)/t2-,4-,5-,8-/m1/s1
• InChIKey: FPGSEBKFEJEOSA-UMMCILCDSA-N
• SMILES: C(C1C(C(C(O1)N2C3=C(C(=O)N=C(N3)N)NC2=O)O)O)O

8-<wbr></wbr>Hydroxyguanosine is produced by oxidative damage of RNA. It can be measured in cell digests or in biological fluids as a marker of oxidative stress. When 8-<wbr></wbr>hydroxyguanosine (5-<wbr></wbr>8 mM) is added to Friend erythroleukemia cells, it acts as a growth inhibitor in addition to promoting differentiation.