8-Hydroxyefavirenz

• CAT Number: R041719
• CAS Number: 205754-33-2
• Molecular Formula: C14H9ClF3NO3
• Molecular Weight: 331.67
• Purity: ≥95%
• Synonyms: (4S)-6-chloro-4-(2-cyclopropylethynyl)-8-hydroxy-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one
• InChI: InChI=1S/C14H9ClF3NO3/c15-8-5-9-11(10(20)6-8)19-12(21)22-13(9,14(16,17)18)4-3-7-1-2-7/h5-7,20H,1-2H2,(H,19,21)/t13-/m0/s1
• InChIKey: OOVOMPCQLMFEDT-ZDUSSCGKSA-N
• SMILES: C1CC1C#C[C@]2(C3=C(C(=CC(=C3)Cl)O)NC(=O)O2)C(F)(F)F

8-Hydroxyefavirenz（Cat No.:R041719）is a metabolite of efavirenz, a widely used antiretroviral drug for the treatment of HIV infection. It is formed through the metabolism of efavirenz in the liver and plays a role in its pharmacological effects. 8-Hydroxyefavirenz is considered one of the primary metabolites of efavirenz, and its concentrations in the bloodstream can affect the drug’s overall efficacy and safety profile. Studies on this metabolite help in understanding the pharmacokinetics, therapeutic effectiveness, and potential side effects of efavirenz, including its impact on long-term treatment outcomes for HIV patients.