8-Hydroxyguanine

• CAT Number: R070056
• CAS Number: 5614-64-2
• Molecular Formula: C5H5N5O2
• Molecular Weight: 167.13
• Purity: ≥95%
• Synonyms: 2-amino-7,9-dihydro-1H-purine-6,8-dione
• InChI: InChI=1S/C5H5N5O2/c6-4-8-2-1(3(11)10-4)7-5(12)9-2/h(H5,6,7,8,9,10,11,12)
• InChIKey: CLGFIVUFZRGQRP-UHFFFAOYSA-N
• SMILES: C12=C(NC(=O)N1)N=C(NC2=O)N

8-Hydroxyguanine is a major pre-mutagenic lesion generated from reactive oxygen species. It causes G-T and A-C substitutions.

Reference

[1]. Arai T, et al. High accumulation of oxidative DNA damage, 8-hydroxyguanine, in Mmh/Ogg1 deficient mice by chronic oxidative stress. Carcinogenesis. 2002 Dec;23(12):2005-10.
 [Content Brief]

[2]. Floyd RA, et al. The role of 8-hydroxyguanine in carcinogenesis. Carcinogenesis. 1990 Sep;11(9):1447-50.
 [Content Brief]

[3]. Cheng KC, et al. 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G—-T and A—-C substitutions. J Biol Chem. 1992 Jan 5;267(1):166-72.
 [Content Brief]