For research use only. Not for therapeutic Use.
8-M-PDOT (AH-002) is a selective melatonin MT2 receptor agonist. 8-M-PDOT is 5.2-fold selective for MT2 over MT1 receptors. 8-M-PDOT binds human recombinant MT2 and MT2 receptors with pKi values of 8.23 and 8.95 respectively. 8-M-PDOT has anxiolytic-like activity[1][2].
8-M-PDOT (10 µg/µL; administrated into the dorsal striatum by bilateral cannulas; for 30 minutes; male Wistar rats) treatment shows anxiolytic-like effect[2].
| Catalog Number | M112976 |
| CAS Number | 134865-70-6 |
| Synonyms | N-(8-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)propanamide |
| Molecular Formula | C14H19NO2 |
| Purity | ≥95% |
| InChI | InChI=1S/C14H19NO2/c1-3-14(16)15-11-8-7-10-5-4-6-13(17-2)12(10)9-11/h4-6,11H,3,7-9H2,1-2H3,(H,15,16) |
| InChIKey | RVIGBTUDFAGRTQ-UHFFFAOYSA-N |
| SMILES | CCC(=O)NC1CCC2=C(C1)C(=CC=C2)OC |
| Reference | [1]. Browning C, et al. Pharmacological characterization of human recombinant melatonin mt(1) and MT(2) receptors. Br J Pharmacol. 2000 Mar;129(5):877-86. [2]. Noseda AC, et al. REM sleep deprivation promotes a dopaminergic influence in the striatal MT2 anxiolytic-like effects. Sleep Sci. 2016 Jan-Mar;9(1):47-54. |
