8-OxoG Clamp CEP

• CAT Number: C001139
• CAS Number: 1134373-47-9
• Molecular Formula: C₅₅H₆₁N₆O₁₁P
• Molecular Weight: 1013.08
• Purity: ≥95%
• Synonyms: N-[2-[[3-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-deoxy-β-D-erythro-pentofuranosyl]-2,3-dihydro-2-oxo-1H-pyrimido[5,4-b][1,4]benzoxazin-9-yl]oxy]ethyl]-phenylmethylester-carbamic Acid; 8-Oxo-dG Clamp CEP
• IUPAC Name: benzyl N-[2-[[3-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]-2-oxo-10H-pyrimido[5,4-b][1,4]benzoxazin-9-yl]oxy]ethyl]carbamate
• InChI: InChI=1S/C55H61N6O11P/c1-37(2)61(38(3)4)73(69-31-14-29-56)72-47-33-50(71-49(47)36-68-55(40-17-11-8-12-18-40,41-21-25-43(64-5)26-22-41)42-23-27-44(65-6)28-24-42)60-34-48-52(59-53(60)62)58-51-45(19-13-20-46(51)70-48)66-32-30-57-54(63)67-35-39-15-9-7-10-16-39/h7-13,15-28,34,37-38,47,49-50H,14,30-33,35-36H2,1-6H3,(H,57,63)(H,58,59,62)/t47-,49+,50+,73?/m0/s1
• InChIKey: KJADXOMZOBCXBS-MNUIYVAGSA-N
• SMILES: CC(C)N(C(C)C)P(OCCC#N)OC1CC(OC1COC(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)C4=CC=C(C=C4)OC)N5C=C6C(=NC5=O)NC7=C(O6)C=CC=C7OCCNC(=O)OCC8=CC=CC=C8

8-OxoG Clamp CEP（Cat No.:C001139）is a specialized phosphoramidite used in DNA synthesis, particularly for introducing the oxidative damage marker 8-oxo-7,8-dihydroguanine (8-OxoG) into oligonucleotides. This compound is essential in studying DNA damage and repair mechanisms, as 8-OxoG is a common lesion resulting from oxidative stress. Incorporating 8-OxoG into DNA sequences allows researchers to investigate its effects on DNA stability, replication, and mutation rates. It is a valuable tool in molecular biology and genetic research, contributing to the understanding of oxidative stress-related diseases and therapeutic development.