For research use only. Not for therapeutic Use.
80-O14B (Cat No.: I040553) is a synthetic small-molecule compound identified as a TLR4 (Toll-like receptor 4) antagonist, designed to inhibit TLR4-mediated innate immune responses. TLR4 plays a critical role in recognizing pathogen-associated molecular patterns like lipopolysaccharides (LPS), triggering pro-inflammatory signaling cascades. By blocking this pathway, 80-O14B helps reduce excessive inflammation and has shown potential in treating inflammatory and autoimmune diseases, such as sepsis, rheumatoid arthritis, and neuroinflammation. It is primarily used in preclinical research to study TLR4 signaling and immune modulation.
| CAS Number | 1624618-01-4 |
| Synonyms | 2-(decyldisulfanyl)ethyl 3-[[3-[2-(decyldisulfanyl)ethoxy]-3-oxopropyl]-[3-(dimethylamino)propyl]amino]propanoate |
| Molecular Formula | C35H70N2O4S4 |
| Purity | ≥95% |
| InChI | InChI=1S/C35H70N2O4S4/c1-5-7-9-11-13-15-17-19-30-42-44-32-28-40-34(38)22-26-37(25-21-24-36(3)4)27-23-35(39)41-29-33-45-43-31-20-18-16-14-12-10-8-6-2/h5-33H2,1-4H3 |
| InChIKey | ZEEOZNKECRKUAC-UHFFFAOYSA-N |
| SMILES | CCCCCCCCCCSSCCOC(=O)CCN(CCCN(C)C)CCC(=O)OCCSSCCCCCCCCCC |
| Reference | [1]. Zhang Feng, et al. Engineering Cpf1 nucleases and viral vectors for delivery of these CRISPR-Cas effector proteins for gene editing and therapeutic applications. World Intellectual Property Organization, WO2018035388 A1 2018-02-22 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
