84-B10

• CAT Number: I041681
• CAS Number: 698346-43-9
• Molecular Formula: C25H22F3NO5
• Molecular Weight: 473.44
• Purity: ≥95%
• Synonyms: 5-[2-(4-methoxyphenoxy)-5-(trifluoromethyl)anilino]-5-oxo-3-phenylpentanoic acid
• InChI: InChI=1S/C25H22F3NO5/c1-33-19-8-10-20(11-9-19)34-22-12-7-18(25(26,27)28)15-21(22)29-23(30)13-17(14-24(31)32)16-5-3-2-4-6-16/h2-12,15,17H,13-14H2,1H3,(H,29,30)(H,31,32)
• InChIKey: UMUXAMJXLBOQNN-UHFFFAOYSA-N
• SMILES: COC1=CC=C(C=C1)OC2=C(C=C(C=C2)C(F)(F)F)NC(=O)CC(CC(=O)O)C3=CC=CC=C3

84-B10 is a 3-phenylglutaric acid derivative. 84-B10 inhibits cisplatin (HY-17394) induced tubular ferroptosis. 84-B10 attenuates cisplatin-induced mitochondrial damage and oxidative stress. 84-B10 ameliorates cisplatin-induced acute kidney injury (AKI)[1].
84-B10 (10-100 μM; 2 h) inhibits cisplatin-induced tubular epithelial cell ferroptosis in a dose-dependent manner[1].
84-B10 (40 μM; 2 h; TKPT cells) restores cisplatin-induced mitochondrial structural damage and dysfunction[1].
84-B10 (40 μM; 2 h; TKPT cells) attenuates mtROS-induced oxidative stress in cisplatin-induced AKI[1].
84-B10 (40 μM; 2 h; TKPT cells) attenuates cisplatin-induced epithelial cell injury by eliminating mtROS and restoring mitochondrial homeostasis[1].
84-B10 (5-15 mg/kg; i.p.) alleviates cisplatin-induced acute kidney injury in mice[1].

Reference

[1]. Fan J, et, al. A novel 3-phenylglutaric acid derivative (84-B10) alleviates cisplatin-induced acute kidney injury by inhibiting mitochondrial oxidative stress-mediated ferroptosis. Free Radic Biol Med. 2023 Jan;194:84-98.
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