9-[[2-Benzyloxy-1-(benzyloxymethyl)-ethoxy]-methyl]-6-chloroguanine-d5

• CAT Number: R008708
• CAS Number: 1184968-31-7
• Molecular Formula: C23H24ClN5O3
• Molecular Weight: 458.958
• Purity: ≥95%
• Synonyms: 6-Chloro-9-[[2-(phenylmethoxy)-1-[(phenylmethoxy)methyl]ethoxy]methyl]-9H-purin-2-amine-d5; Biolf 70-d5
• Storage: Store at +4C
• IUPAC Name: 6-chloro-9-[[1,1,2,3,3-pentadeuterio-1,3-bis(phenylmethoxy)propan-2-yl]oxymethyl]purin-2-amine
• InChI: InChI=1S/C23H24ClN5O3/c24-21-20-22(28-23(25)27-21)29(15-26-20)16-32-19(13-30-11-17-7-3-1-4-8-17)14-31-12-18-9-5-2-6-10-18/h1-10,15,19H,11-14,16H2,(H2,25,27,28)/i13D2,14D2,19D
• InChIKey: ZXJUDIFIAGSPQH-URHBMTNZSA-N
• SMILES: [2H]C([2H])(C([2H])(C([2H])([2H])OCC1=CC=CC=C1)OCN2C=NC3=C2N=C(N=C3Cl)N)OCC4=CC=CC=C4

9-[[2-Benzyloxy-1-(benzyloxymethyl)-ethoxy]-methyl]-6-chloroguanine-d5 is a deuterium-labeled derivative of a synthetic nucleoside analogue. It targets viral DNA polymerase, inhibiting viral replication by incorporation into viral DNA. This compound is crucial in pharmaceutical research for the development and study of antiviral drugs, particularly those targeting herpesviruses. The deuterium labeling allows for detailed mass spectrometry analysis, aiding in pharmacokinetic and metabolic studies. In organic chemistry, it serves as a reference standard for synthesis and analytical method validation, ensuring accurate quantification in complex biological matrices and enhancing the reliability of antiviral drug research.