9-((2-phosphonylmethoxy)ethyl)guanine

• CAT Number: M019453
• CAS Number: 114088-58-3
• Molecular Formula: C8H12N5O5P
• Molecular Weight: 289.19
• Purity: ≥95%
• Storage: Store at +4C
• IUPAC Name: 2-(2-amino-6-oxo-1H-purin-9-yl)ethoxymethylphosphonic acid
• InChI: InChI=1S/C8H12N5O5P/c9-8-11-6-5(7(14)12-8)10-3-13(6)1-2-18-4-19(15,16)17/h3H,1-2,4H2,(H2,15,16,17)(H3,9,11,12,14)
• InChIKey: NZVORGQIEFTOQZ-UHFFFAOYSA-N
• SMILES: C1=NC2=C(N1CCOCP(=O)(O)O)N=C(NC2=O)N

9-((2-Phosphonylmethoxy)ethyl)guanine（Cat No.:M019453）, commonly known as PMEG, is a synthetic antiviral compound. It belongs to the class of acyclic nucleoside phosphonates, which mimic the natural building blocks of DNA. This structure enables PMEG to act as a potent inhibitor of viral DNA polymerases, thereby blocking the replication of viruses. It is particularly effective against cytomegalovirus (CMV) and other herpesviruses, which makes it a candidate for treating infections caused by these pathogens. The phosphonate group confers improved stability and bioavailability compared to other nucleoside analogs, enhancing its therapeutic potential in antiviral therapy.