9-Amino Camptothecin

• CAT Number: R058830
• CAS Number: 91421-43-1
• Molecular Formula: C20H17N3O4
• Molecular Weight: 363.4
• Purity: ≥95%
• Synonyms: (4S)-10-Amino-4-ethyl-4-hydroxy-1H-pyrano[3’,4’:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; 9-Amino-20(S)-camptothecin; 9-Aminocamptothecin; NSC 60307
• Target: Topoisomerase
• Solubility: Soluble in DMSO
• Storage: Store at -20°C
• InChIKey: FUXVKZWTXQUGMW-FQEVSTJZSA-N

9-Amino Camptothecin is a synthetic derivative of camptothecin, a natural alkaloid originally isolated from the Camptotheca acuminata tree. It is an antineoplastic agent with potent anticancer activity, primarily through its inhibition of topoisomerase I, an enzyme crucial for DNA replication and transcription. By stabilizing the complex between topoisomerase I and DNA, 9-Amino Camptothecin induces DNA damage, leading to apoptosis in rapidly dividing cancer cells. It has shown promise in preclinical and clinical studies for treating various cancers, including colorectal, ovarian, and lung cancers, making it a valuable candidate in oncology research.