For research use only. Not for therapeutic Use.
9-Amino Camptothecin is a synthetic derivative of camptothecin, a natural alkaloid originally isolated from the Camptotheca acuminata tree. It is an antineoplastic agent with potent anticancer activity, primarily through its inhibition of topoisomerase I, an enzyme crucial for DNA replication and transcription. By stabilizing the complex between topoisomerase I and DNA, 9-Amino Camptothecin induces DNA damage, leading to apoptosis in rapidly dividing cancer cells. It has shown promise in preclinical and clinical studies for treating various cancers, including colorectal, ovarian, and lung cancers, making it a valuable candidate in oncology research.
| Catalog Number | R058830 |
| CAS Number | 91421-43-1 |
| Synonyms | (4S)-10-Amino-4-ethyl-4-hydroxy-1H-pyrano[3’,4’:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; 9-Amino-20(S)-camptothecin; 9-Aminocamptothecin; NSC 60307; |
| Molecular Formula | C20H17N3O4 |
| Purity | ≥95% |
| Target | Topoisomerase |
| Solubility | Soluble in DMSO |
| Storage | Store at -20°C |
| InChIKey | FUXVKZWTXQUGMW-FQEVSTJZSA-N |
