For research use only. Not for therapeutic Use.
9-Amino-NeuAc is a substrate of synthase. 9-Amino-NeuAc can be converted to CMP9-amino-NeuAc, activated to the corresponding CMPglycoside and transferred to asialoglycoprotein. 9-Amino-NeuAc can be used to target liposome synthesis while modulating tumor surface immunogenicity[1][2].
| Catalog Number | I040930 |
| CAS Number | 153232-60-1 |
| Synonyms | (2S,4S,5R,6R)-5-acetamido-6-[(1R,2R)-3-amino-1,2-dihydroxypropyl]-2,4-dihydroxyoxane-2-carboxylic acid |
| Molecular Formula | C11H20N2O8 |
| Purity | ≥95% |
| InChI | InChI=1S/C11H20N2O8/c1-4(14)13-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-12/h5-9,15-17,20H,2-3,12H2,1H3,(H,13,14)(H,18,19)/t5-,6+,7+,8+,9+,11-/m0/s1 |
| InChIKey | PSFLJKJWZHEYMD-PFQGKNLYSA-N |
| SMILES | CC(=O)NC1C(CC(OC1C(C(CN)O)O)(C(=O)O)O)O |
| Reference | [1]. Zheng N, et al. Liposome-aided metabolic engineering of tumor surface immunogenicity. Bioorg Med Chem Lett. 2018 Aug 1;28(14):2550-2554. [2]. Gross H J, et al. Asialo-伪 1-acid glycoprotein resialylated with 9-amino-5-N-acetyl-d-neuraminic acid is resistant towards bacterial, viral and mammalian sialidases[J]. Glycoconjugate Journal, 1988, 5: 411-417. |
