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Home > Reference Standards> > 9-CHLORO-2-(2-FURANYL)-5-[(PHENYLACETY)AMINO][1,2,4]-TRIAZOLO[1,5-C] QUINAZOLINE
183721-15-5-9-CHLORO-2-(2-FURANYL)-5-[(PHENYLACETY)AMINO][1,2,4]-TRIAZOLO[1,5-C] QUINAZOLINE 9-CHLORO-2-(2-FURANYL)-5-[(PHENYLACETY)AMINO][1,2,4]-TRIAZOLO[1,5-C] QUINAZOLINE

9-CHLORO-2-(2-FURANYL)-5-[(PHENYLACETY)AMINO][1,2,4]-TRIAZOLO[1,5-C] QUINAZOLINE

For research use only. Not for therapeutic Use.

  • CAT Number: M035035
  • CAS Number: 183721-15-5
  • Molecular Formula: C21H14ClN5O2
  • Molecular Weight: 403.826
  • Purity: ≥95%
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Related Small Molecules: 2,5-Bis-Thiopheneboronic acid pinacol ester     Lumiflavin-3-acetic Acid Ethyl Ester     2,3,4,4,6-Pentachlorobiphenyl    

MRS1220 is a potent and highly selective antagonist at the human A3 adenosine receptor (Ki values are 0.65, 305, and 52 nM at hA3, rA1 and rA2A respectively. MRS1220 displays an IC50 value > 1 μM for inhibition of binding to rat A3 receptors.


Catalog Number M035035
CAS Number 183721-15-5
Synonyms

N-(9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]quinazolin-5-yl)-2-phenylacetamide

Molecular Formula C21H14ClN5O2
Purity ≥95%
Target Adenosine Receptor
Solubility Soluble in DMSO > 10 mM
Storage Store at RT
IUPAC Name N-[9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]quinazolin-5-yl]-2-phenylacetamide
InChI InChI=1S/C21H14ClN5O2/c22-14-8-9-16-15(12-14)20-25-19(17-7-4-10-29-17)26-27(20)21(23-16)24-18(28)11-13-5-2-1-3-6-13/h1-10,12H,11H2,(H,23,24,28)
InChIKey TWWFAXQOKNBUCR-UHFFFAOYSA-N
SMILES C1=CC=C(C=C1)CC(=O)NC2=NC3=C(C=C(C=C3)Cl)C4=NC(=NN42)C5=CC=CO5
Reference

</br>1: Stoddart LA, Vernall AJ, Briddon SJ, Kellam B, Hill SJ. Direct visualisation of internalization of the adenosine A3 receptor and localization with arrestin3 using a fluorescent agonist. Neuropharmacology. 2015 Nov;98:68-77. doi: 10.1016/j.neuropharm.2015.04.013. PubMed PMID: 25937210.</br>2: D/’Alimonte I, Nargi E, Zuccarini M, Lanuti P, Di Iorio P, Giuliani P, Ricci-Vitiani L, Pallini R, Caciagli F, Ciccarelli R. Potentiation of temozolomide antitumor effect by purine receptor ligands able to restrain the in vitro growth of human glioblastoma stem cells. Purinergic Signal. 2015 Sep;11(3):331-46. doi: 10.1007/s11302-015-9454-7. PubMed PMID: 25976165; PubMed Central PMCID: PMC4529851.</br></br>

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