9-Fluorenol

• CAT Number: R022983
• CAS Number: 1689-64-1
• Molecular Formula: C13H10O
• Molecular Weight: 182.22
• Purity: ≥95%
• Synonyms: 9H-fluoren-9-ol
• InChI: InChI=1S/C13H10O/c14-13-11-7-3-1-5-9(11)10-6-2-4-8-12(10)13/h1-8,13-14H
• InChIKey: AFMVESZOYKHDBJ-UHFFFAOYSA-N
• SMILES: C1=CC=C2C(=C1)C(C3=CC=CC=C32)O

9-Fluorenol (9-Hydroxyfluorene; compound 3) is a dopamine (DAT) inhibitor with IC50 value of 9 µM. 9-Fluorenol is a major metabolite of compound developed as a wake promoting agent. 9-Fluorenol shows wake promotion activity in vivo[1].
1.19

Pharmacokinetic parameters of 9-Fluorenol (100 mg/kg; i.p.) in rats[1]

Plasma
Brain

Cmax , ng/g
263
4384

tmax , h
2
0.8

AUC0-t , ng h/g
1081
11639

Reference

[1]. Dunn D, et al. Wake promoting agents: search for next generation modafinil, lessons learned: part III. Bioorg Med Chem Lett. 2012 Jun 1;22(11):3751-3.
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