For research use only. Not for therapeutic Use.
9-Hydroxyoctadecanoic acid (9-HSA) is an HDAC1 inhibitor that inhibits ∼66.4% HDAC1 enzymatic activity at 5 μM. 9-Hydroxyoctadecanoic acid shows anticancer activity[1].
9-Hydroxyoctadecanoic acid (9-HSA) can bind to the active site of the three-dimensional model of the human HDAC1 protein[1].
9-Hydroxyoctadecanoic acid (9-HSA) (100 μM; 24 h) inhibits HT29 cell proliferation, induces arrest in G0/G1, and increases p21WAF1 expression both at the transcriptional and the translational levels[2].
| Catalog Number | I041262 |
| CAS Number | 3384-24-5 |
| Synonyms | 9-hydroxyoctadecanoic acid |
| Molecular Formula | C18H36O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C18H36O3/c1-2-3-4-5-6-8-11-14-17(19)15-12-9-7-10-13-16-18(20)21/h17,19H,2-16H2,1H3,(H,20,21) |
| InChIKey | RKHXDCVAPIMDMG-UHFFFAOYSA-N |
| SMILES | CCCCCCCCCC(CCCCCCCC(=O)O)O |
| Reference | [1]. Calonghi N, et al. Histone deacetylase 1: a target of 9-hydroxystearic acid in the inhibition of cell growth in human colon cancer. J Lipid Res. 2005 Aug;46(8):1596-603. [2]. Calonghi N, et al. 9-Hydroxystearic acid upregulates p21(WAF1) in HT29 cancer cells. Biochem Biophys Res Commun. 2004 Jan 30;314(1):138-42. |
