9-Methoxycamptothecin

• CAT Number: R072397
• CAS Number: 39026-92-1
• PubChem Substance ID: 123617
• Molecular Formula: C21H18N2O5
• Molecular Weight: 378.38
• Purity: ≥95%
• IUPAC Name: (19S)-19-ethyl-19-hydroxy-8-methoxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione
• InChI: InChI=1S/C21H18N2O5/c1-3-21(26)14-8-16-18-11(7-12-15(22-18)5-4-6-17(12)27-2)9-23(16)19(24)13(14)10-28-20(21)25/h4-8,26H,3,9-10H2,1-2H3/t21-/m0/s1
• InChIKey: XVMZDZFTCKLZTF-NRFANRHFSA-N
• SMILES: CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=CC5=C(C=CC=C5OC)N=C4C3=C2)O

9-Methoxycamptothecin（Cat No.:R072397）is a synthetic derivative of camptothecin, a natural alkaloid known for its potent anti-cancer properties. This compound functions as a topoisomerase I inhibitor, disrupting DNA replication and leading to cell death in rapidly dividing cancer cells. 9-Methoxycamptothecin has shown enhanced stability and reduced toxicity compared to its parent compound, making it a promising candidate in cancer therapy. It has demonstrated efficacy in preclinical studies against various tumors, including colorectal and ovarian cancers. Ongoing research aims to further explore its therapeutic potential and optimize its application in clinical settings.