For research use only. Not for therapeutic Use.
Nitrated unsaturated fatty acids, such as 10-<wbr></wbr> and 12-<wbr></wbr>nitrolinoleate (LNO<sub>2</sub>; Item No. <span class=/itemid/>10037</span>), cholesteryl nitrolinoleate, and nitrohydroxylinoleate, represent a new class of endogenous lipid-<wbr></wbr>derived signalling molecules. LNO<sub>2</sub> isomers serve as potent endogenous ligands for PPARγ and can also decompose or be metabolized to release nitric oxide. 9-<wbr></wbr>Nitrooleate is one of two regioisomers of nitrooleate, the other being 10-<wbr></wbr>nitrooleate (Item No. <span class=/itemid/>10008043</span>) (OA-<wbr></wbr>NO<sub>2</sub>; used for the mixture of isomers), which are formed by nitration of oleic acid in approximately equal proportions <em>in vivo</em>. Peroxynitrite, acidified nitrite, and myeloperoxidase in the presence of H<sub>2</sub>O<sub>2</sub> and nitrite, all mediate the nitration of oleic acid. OA-<wbr></wbr>NO<sub>2</sub> is found in human plasma as the free acid and esterified in phospholipids at concentrations of 619 ± 52 nM and 302 ± 369 nM, respectively. OA-<wbr></wbr>NO<sub>2</sub> activates PPARγ approximately 7-<wbr></wbr>fold at a concentration of 1 µM and effectively promotes differentiation 3T3-<wbr></wbr>L1 preadipocytes to adipocytes at 3 µM.
| Catalog Number | R055019 |
| CAS Number | 875685-44-2 |
| Synonyms | (9E)-9-Nitro-9-octadecenoic Acid; |
| Molecular Formula | C18H33NO4 |
| Purity | ≥95% |
| Storage | -20°C |
| InChIKey | CQOAKBVRRVHWKV-SAPNQHFASA-N |
