9,10-Dihydroergocristine Methanesulfonate

• CAT Number: R041680
• CAS Number: 24730-10-7
• Molecular Formula: C36H45N5O8S
• Molecular Weight: 707.843
• Purity: ≥95%
• Synonyms: (5’α,10α)-9,10-Dihydro-12’-hydroxy-2’-(1-methylethyl)-5’-(phenylmethyl)-ergotaman-3’,6’,18-trione Methansulfonate; 9,10-Dihydro-12’-hydroxy-2’-(1-methylethyl)-5’-(phenylmethyl)-ergotaman-3’,6’,18-trione Monomethanesulfonate; Dihydroergocristine Mesy
• Target: Amyloid-β
• Solubility: Soluble in DMSO > 10 mM
• Storage: Store at RT
• InChI: InChI=1S/C35H41N5O5.CH4O3S/c1-20(2)34(37-31(41)23-16-25-24-11-7-12-26-30(24)22(18-36-26)17-27(25)38(3)19-23)33(43)40-28(15-21-9-5-4-6-10-21)32(42)39-14-8-13-29(39)35(40,44)45-34;1-5(2,3)4/h4-7,9-12,18,20,23,25,27-29,36,44H,8,13-17,19H2,1-3H3,(H,37,41);1H3,(H,2,3,4)/t23-,25-,27-,28+,29+,34-,35+;/m1./s1
• InChIKey: SPXACGZWWVIDGR-SPZWACKZSA-N
• SMILES: CC(C)C1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CC6C(CC7=CNC8=CC=CC6=C78)N(C5)C.CS(=O)(=O)O

9,10-Dihydroergocristine methanesulfonate is a semi-synthetic ergot alkaloid derivative, primarily used for its vasodilatory and neuroprotective properties. It is commonly applied in the treatment of cognitive disorders and vascular conditions, such as peripheral vascular disease and dementia. The methanesulfonate salt enhances its solubility and bioavailability, making it more effective for therapeutic use. As part of the ergoline family, it interacts with serotonin and dopamine receptors, contributing to improved blood circulation and cognitive function in medical applications.