For research use only. Not for therapeutic Use.
(9E)-Lumefantrine (CAT: C000249) is an isomer of Lumefantrine, known for its pharmacologic action as an antimalarial agent. Its mode of action centers on inhibiting hemozoin formation in Plasmodium falciparum, the parasite responsible for malaria. Hemozoin is a toxic byproduct generated during the parasite’s digestion of hemoglobin in red blood cells.
| Catalog Number | C000249 |
| CAS Number | 1456736-33-6 |
| Synonyms | (9E)-2,7-Dichloro-9-[(4-chlorophenyl)methylene]-?-[(dibutylamino)methyl]-9H-fluorene-4-methanol |
| Molecular Formula | C₃₀H₃₂Cl₃NO |
| Purity | ≥95% |
| Solubility | Benzene (Slightly), Chloroform (Slightly), Ethyl Acetate (Slightly) |
| Appearance | Pale Yellow to Light Yellow Sticky Solid |
| Storage | 4°C, Inert atmosphere |
| Reference | Kumar, N., et al.: Parasitol Res., 76, 214 (1990); Pradines, B., et al.: Antimicrob. Agents Chemother., 43, 418 (1999); Chotivanich, K., et al.: J. Infect. Dis., 182, 629 (2000); Mutabingwa, T., et al.: Lancet, 365, 1474 (2005) |
