PXS 4728 HCl


CAS No. : 1478364-68-9

PXS 4728 HCl,1478364-68-9
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I008921
Synonyms:PXS-4728A; PXS4728A; PXS 4728A;(E)-4-((2-(aminomethyl)-3-fluoroallyl)oxy)-N-(tert-butyl)benzamide hydrochloride
Molecular Formula:C15H22ClFN2O2
Molecular Weight:316.8014
Target:SSAO/VAP Inhibitor
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Appearance:Solid powder
Purity:98%
Cat No:I008921
Cas No:1478364-68-9
Product-Name:PXS 4728 HCl
IUPAC Name:4-[(E)-2-(aminomethyl)-3-fluoroprop-2-enoxy]-N-tert-butylbenzamide;hydrochloride
InChI:InChI=1S/C15H21FN2O2.ClH/c1-15(2,3)18-14(19)12-4-6-13(7-5-12)20-10-11(8-16)9-17;/h4-8H,9-10,17H2,1-3H3,(H,18,19);1H/b11-8+;
InChIKey:AEMZEDNMNLIDSL-YGCVIUNWSA-N
SMILES:O=C(NC(C)(C)C)C1=CC=C(OC/C(CN)=C/F)C=C1.[H]Cl
PXS-4728A(cas 1478364-68-9) is a SSAO/VAP inhibitor potentially for the treatment of non-alcoholic steatohepatitis. VAP-1/SSAO contributes to the migration of neutrophils during acute lung inflammation, pulmonary infection and airway hyperractivity. Selective VAP-1/SSAO inhibition by PXS-4728A diminished leukocyte rolling and adherence induced by CXCL1/KC. Inhibition of VAP-1/SSAO also dampened the migration of neutrophils to the lungs in response to LPS, Klebsiella pneumoniae lung infection and CLP induced sepsis; whilst still allowing for normal neutrophil defense function, resulting in increased survival.

1:The inhibitor of semicarbazide-sensitive amine oxidase, PXS-4728A, ameliorates key features of chronic obstructive pulmonary disease in a mouse model. Jarnicki AG, Schilter H, Liu G, Wheeldon K, Essilfie AT, Foot JS, Yow TT, Jarolimek W, Hansbro PM.Br J Pharmacol. 2016 Nov;173(22):3161-3175. doi: 10.1111/bph.13573. Epub 2016 Oct 12. PMID: 27495192
2:Effects of an anti-inflammatory VAP-1/SSAO inhibitor, PXS-4728A, on pulmonary neutrophil migration. Schilter HC, Collison A, Russo RC, Foot JS, Yow TT, Vieira AT, Tavares LD, Mattes J, Teixeira MM, Jarolimek W.Respir Res. 2015 Mar 20;16:42. doi: 10.1186/s12931-015-0200-z. PMID: 25889951 Free PMC Article
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