CAS No. : 170157-13-8

Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:P000420
Molecular Formula:C80H102ClN15O14
Molecular Weight:1533.237
Target:GnRH antagonist
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Appearance:Solid powder
Purity: > 98%
Cat No:P000420
Cas No:170157-13-8
Acyline is a novel GnRH antagonist found in animal studies to be a potent suppressor of circulating gonadotropin and testosterone (T) levels. Acyline inhibits basal and GnRH-stimulated serum testosterone concentrations in male dogs. Acyline prevented ovulation, but did not affect ovarian follicular development or gestational corpora lutea in the domestic cat. A single dose of the potent gonadotropin-releasing hormone antagonist acyline suppresses gonadotropins and testosterone for 2 weeks in healthy young men.

1:Treatment of canine pyometra with the gonadotropin-releasing hormone antagonist acyline: a case series. Batista PR, Blanco PG, Gobello C.Top Companion Anim Med. 2015 Mar;30(1):25-7. doi: 10.1053/j.tcam.2015.01.005. Epub 2015 Feb 4. PMID: 26041594
2:Photoperiod-gonadotropin mismatches induced by treatment with acyline or FSH in Siberian hamsters: impacts on ovarian structure and function. Zysling DA, Park SU, McMillan EL, Place NJ.Reproduction. 2012 Nov;144(5):603-16. doi: 10.1530/REP-12-0155. Epub 2012 Aug 30. PMID: 22936286 Free Article
3:Effects of the GnRH antagonist acyline on the testis of the domestic cat (Felis catus). Garcia Romero G, Fernández PE, Gimeno E, Barbeito C, Gobello C.Vet J. 2012 Jul;193(1):279-82. doi: 10.1016/j.tvjl.2011.09.028. Epub 2011 Nov 8. PMID: 22070915
4:A single administration of the GnRH antagonist acyline inhibits basal and GnRH-stimulated serum testosterone concentrations in male dogs. García Romero G, Mattioli G, Rosa D, Diaz JD, Abeyá M, Gobello C.Reprod Domest Anim. 2012 Jun;47(3):e32-5. doi: 10.1111/j.1439-0531.2011.01898.x. Epub 2011 Nov 1. PMID: 22044671
5:The GnRH antagonist acyline prevented ovulation, but did not affect ovarian follicular development or gestational corpora lutea in the domestic cat. Risso A, Valiente C, Corrada Y, Romero GG, Blanco PG, de la Sota PE, Diaz JD, Gobello C.Theriogenology. 2010 Apr 15;73(7):984-7. doi: 10.1016/j.theriogenology.2010.01.010. Epub 2010 Feb 19. PMID: 20171723
6:Comparison of two doses of the GnRH antagonist, acyline, for pregnancy termination in bitches. Valiente C, Corrada Y, de la Sota PE, Blanco PG, Arias D, Gobello C.Reprod Domest Anim. 2009 Jul;44 Suppl 2:156-9. doi: 10.1111/j.1439-0531.2009.01397.x. PMID: 19754557
7:Oral administration of the GnRH antagonist acyline, in a GIPET-enhanced tablet form, acutely suppresses serum testosterone in normal men: single-dose pharmacokinetics and pharmacodynamics. Amory JK, Leonard TW, Page ST, O/'Toole E, McKenna MJ, Bremner WJ.Cancer Chemother Pharmacol. 2009 Aug;64(3):641-5. doi: 10.1007/s00280-009-1038-1. Epub 2009 May 29. PMID: 19479252 Free PMC Article
8:Endocrine effects of the GnRH antagonist, acyline, in domestic dogs. García Romero G, Valiente C, Aquilano D, Corrada Y, Gobello C.Theriogenology. 2009 May;71(8):1234-7. doi: 10.1016/j.theriogenology.2008.12.017. Epub 2009 Feb 3. PMID: 19193431
9:Effect of suppression of FSH with a GnRH antagonist (acyline) before and during follicle deviation in the mare. Checura CM, Beg MA, Gastal EL, Gastal MO, Wiltbank MC, Parrish JJ, Ginther OJ.Reprod Domest Anim. 2009 Jun;44(3):504-11. doi: 10.1111/j.1439-0531.2008.01222.x. Epub 2008 Oct 10. PMID: 18954386
10:Interruption of the canine estrous cycle with a low and a high dose of the GnRH antagonist, acyline. Valiente C, Romero GG, Corrada Y, de la Sota PE, Hermo G, Gobello C.Theriogenology. 2009 Feb;71(3):408-11. doi: 10.1016/j.theriogenology.2008.08.007. Epub 2008 Sep 11. PMID: 18789519
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