|Product-Name:||Adenosine 5'-diphosphate (potassium salt)|
Adenosine 5/'-diphosphate (ADP) is an adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5’ position. It is produced by dephosphorylation of adenosine 5’-triphosphate (ATP; Item No. 14498) by ATPases and can be converted back to ATP by ATP synthases. ADP can also be metabolized to adenosine 5’-monophosphate (AMP; Item No. 21094) and 2’-deoxyadenosine 5’-diphosphate (dADP). ADP can modulate several receptors, activating certain purinergic receptors (EC50 = 24 nM for P2Y1) and inhibiting others (IC50 = 67 nM for P2X2/3), inhibiting rat ecto-5’nucleotidase (Ki = 0.91 nM), and regulating the phosphorylation status of AMP-activated protein kinase (AMPK).
1.Azran, S.,Förster, D.,Danino, O., et al. Highly efficient biocompatible neuroprotectants with dual activity as antioxidants and P2Y receptor agonists. J. Med. Chem. 56(12), 4938-4952 (2013).