A 1120

• CAT Number: I010822
• CAS Number: 1152782-19-8
• Molecular Formula: C20H19F3N2O3
• Molecular Weight: 392.378
• Purity: ≥95%
• Synonyms: 2-(4-(2-(Trifluoromethyl)phenyl)piperidine-1-carboxamido)benzoic acid
• Target: Transthyretin (TTR)
• Solubility: Soluble to 100 mM in DMSO and to 25 mM in ethanol
• Storage: Store at RT
• IUPAC Name: 2-[[4-[2-(trifluoromethyl)phenyl]piperidine-1-carbonyl]amino]benzoic acid
• InChI: InChI=1S/C20H19F3N2O3/c21-20(22,23)16-7-3-1-5-14(16)13-9-11-25(12-10-13)19(28)24-17-8-4-2-6-15(17)18(26)27/h1-8,13H,9-12H2,(H,24,28)(H,26,27)
• InChIKey: MEAQCLPMSVEOQF-UHFFFAOYSA-N
• SMILES: C1CN(CCC1C2=CC=CC=C2C(F)(F)F)C(=O)NC3=CC=CC=C3C(=O)O

A 1120 (CAT: I010822) is a significant compound acting as a high-affinity ligand for retinol-binding protein 4 (RBP4), a carrier protein involved in the transport of retinol (vitamin A) in the blood. A 1120 binds to RBP4 with a notable Ki value of 8.3 nM. This compound’s interaction with RBP4 highlights its potential as a modulator of retinol transport and metabolism. Additionally, A 1120’s selectivity against a range of cellular targets, as well as its ability to effectively displace transthyretin (TTR) from RBP4-TTR complexes, underscores its significance in understanding retinol-binding protein interactions.