For research use only. Not for therapeutic Use.
A-1155463（Cat No.:I000937） is a potent and selective inhibitor of B-cell lymphoma-extra large (BCL-XL), which plays a key role in regulating apoptosis or programmed cell death. The drug binds to BCL-XL with high affinity at the picomolar level and exhibits more than 1000 times weaker binding affinity to BCL-2, BCL-W (Ki=19nM), and MCL-1 (Ki>440nM). The selective inhibition of BCL-XL by A-1155463 induces apoptosis in cancer cells and has shown promising anti-tumor activity in preclinical studies.
| Catalog Number | I000937 |
| CAS Number | 1235034-55-5 |
| Synonyms | 2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(3-(4-(3-(dimethylamino)prop-1-yn-1-yl)-2-fluorophenoxy)propyl)thiazole-4-carboxylic acid |
| Molecular Formula | C₃₅H₃₂FN₅O₄S₂ |
| Purity | ≥95% |
| Target | Bcl-2 Family |
| Solubility | DMSO: ≥ 31 mg/mL |
| Storage | Store at -20°C |
| IC50 | ＜0.01 nM (Ki) [1] |
| IUPAC Name | 2-[8-(1,3-benzothiazol-2-ylcarbamoyl)-3,4-dihydro-1H-isoquinolin-2-yl]-5-[3-[4-[3-(dimethylamino)prop-1-ynyl]-2-fluorophenoxy]propyl]-1,3-thiazole-4-carboxylic acid |
| InChI | InChI=1S/C35H32FN5O4S2/c1-40(2)17-6-8-22-14-15-28(26(36)20-22)45-19-7-13-30-31(33(43)44)38-35(47-30)41-18-16-23-9-5-10-24(25(23)21-41)32(42)39-34-37-27-11-3-4-12-29(27)46-34/h3-5,9-12,14-15,20H,7,13,16-19,21H2,1-2H3,(H,43,44)(H,37,39,42) |
| InChIKey | SOYCFODXNRVBTI-UHFFFAOYSA-N |
| SMILES | CN(C)CC#CC1=CC(=C(C=C1)OCCCC2=C(N=C(S2)N3CCC4=CC=CC(=C4C3)C(=O)NC5=NC6=CC=CC=C6S5)C(=O)O)F |
| Reference | <p style=/line-height:25px/> |
