For research use only. Not for therapeutic Use.
A-1331852 (CAT: I000170) is a potent and selective inhibitor of the anti-apoptotic protein MCL-1. It binds to MCL-1 with high affinity, disrupting its interaction with pro-apoptotic proteins, thereby promoting apoptosis in cancer cells. A-1331852 exhibits anticancer activity against various cancer cell lines, including solid tumors and hematological malignancies, by selectively targeting MCL-1-dependent cell survival pathways. It has shown promising preclinical results and is being investigated as a potential therapeutic agent for the treatment of cancers that depend on MCL-1 for survival.
| Catalog Number | I000170 |
| CAS Number | 1430844-80-6 |
| Synonyms | A-1331852; A 1331852; A1331852.;3-(1-(((3r,5r,7r)-adamantan-1-yl)methyl)-5-methyl-1H-pyrazol-4-yl)-6-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)picolinic acid |
| Molecular Formula | C₃₈H₃₈N₆O₃S |
| Purity | ≥95% |
| Target | Bcl-2 Family |
| Solubility | Soluble in DMSO |
| Storage | Store at -20°C |
| IC50 | Ki: 6 nM for BCL-2 TR-FRET |
| InChI | InChI=1S/C38H38N6O3S/c1-22-29(19-39-44(22)21-38-16-23-13-24(17-38)15-25(14-23)18-38)27-9-10-33(41-34(27)36(46)47)43-12-11-26-5-4-6-28(30(26)20-43)35(45)42-37-40-31-7-2-3-8-32(31)48-37/h2-10,19,23-25H,11-18,20-21H2,1H3,(H,46,47)(H,40,42,45) |
| InChIKey | QCQQONWEDCOTBV-UHFFFAOYSA-N |
| SMILES | CC1=C(C=NN1CC23CC4CC(C2)CC(C4)C3)C5=C(N=C(C=C5)N6CCC7=CC=CC(=C7C6)C(=O)NC8=NC9=CC=CC=C9S8)C(=O)O |
| Reference | <p> |
