For research use only. Not for therapeutic Use.
A-196(Cat No.:R065702)is a selective inhibitor of the protein arginine methyltransferase PRMT1, which is involved in regulating gene expression and various cellular processes through the methylation of arginine residues. By inhibiting PRMT1, A-196 can disrupt oncogenic signaling pathways and has shown promise in preclinical studies for its anti-cancer effects, particularly in cancers characterized by elevated PRMT1 activity. Additionally, A-196 may influence cellular differentiation and apoptosis. Its unique mechanism of action highlights its potential as a therapeutic agent in cancer treatment, offering insights into targeting methylation-related pathways for novel therapies.
Catalog Number | R065702 |
CAS Number | 1982372-88-2 |
Synonyms | 6,7-dichloro-N-cyclopentyl-4-(4-pyridinyl)-1-phthalazinamine |
Molecular Formula | C18H16Cl2N4 |
Purity | ≥95% |
Target | Histone Methyltransferase |
Storage | -20°C |
IUPAC Name | 6,7-dichloro-N-cyclopentyl-4-pyridin-4-ylphthalazin-1-amine |
InChI | InChI=1S/C18H16Cl2N4/c19-15-9-13-14(10-16(15)20)18(22-12-3-1-2-4-12)24-23-17(13)11-5-7-21-8-6-11/h5-10,12H,1-4H2,(H,22,24) |
InChIKey | ABGOSOMRWSYAOB-UHFFFAOYSA-N |
SMILES | C1CCC(C1)NC2=NN=C(C3=CC(=C(C=C32)Cl)Cl)C4=CC=NC=C4 |
Reference | 1. Nat Chem Biol. 2017 Mar;13(3):317-324. doi: 10.1038/nchembio.2282. Epub 2017 Jan The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity. |