A-552

• CAT Number: I021105
• Molecular Formula: C28H27N3O4
• Molecular Weight: 469.54
• Purity: 98%
• Synonyms: A-552; A 552; A552
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: (S)-2-((4-(3-Amino-4-methylphenyl)-6-methylpyrimidin-2-yl)oxy)-3-methoxy-3,3-diphenylpropanoic acid
• InChI: InChI=1S/C28H27N3O4/c1-18-14-15-20(17-23(18)29)24-16-19(2)30-27(31-24)35-25(26(32)33)28(34-3,21-10-6-4-7-11-21)22-12-8-5-9-13-22/h4-17,25H,29H2,1-3H3,(H,32,33)/t25-/m1/s1
• InChIKey: GDPBXJYDHBGQBK-RUZDIDTESA-N
• SMILES: O=C(O)[C@@H](OC1=NC(C)=CC(C2=CC=C(C)C(N)=C2)=N1)C(C3=CC=CC=C3)(OC)C4=CC=CC=C4

A-552(CAT: I021105) is a first-in-class, potent antagonist of human interleukin-36γ (IL-36γ), showing high specificity while sparing the closely related IL-36α. This compound is widely utilized in immunology and inflammatory disease research for studying IL-36γ-mediated signaling pathways. By selectively inhibiting IL-36γ, A-552 provides valuable insights into its role in autoimmune and inflammatory conditions, such as psoriasis and inflammatory bowel disease (IBD). Its high specificity makes it an essential tool for preclinical studies aimed at understanding the distinct biological functions of IL-36 family cytokines and developing targeted therapies for IL-36γ-driven inflammatory disorders.