For research use only. Not for therapeutic Use.
A-582941 (CAT: I000286) is a novel agonist of the alpha7 subtype of nicotinic acetylcholine receptors (nAChRs). By binding and activating the alpha7 nAChR, A-582941 modulates downstream signaling pathways associated with neurotransmission, cognitive function, and inflammation. Its selective agonistic activity at the alpha7 nAChR makes A-582941 a promising compound for potential therapeutic applications in neurological disorders such as Alzheimer’s disease, schizophrenia, and cognitive impairments. Further exploration of A-582941’s effects on alpha7 nAChR activation may provide valuable insights into the development of treatments targeting this receptor subtype.
| Catalog Number | I000286 |
| CAS Number | 848591-89-9 |
| Synonyms | A-582941;3-{5-methyl-octahydropyrrolo[3,4-c]pyrrol-2-yl}-6-phenylpyridazine |
| Molecular Formula | C17H20N4 |
| Purity | ≥95% |
| Target | alpha7 nicotinic acetylcholine receptor agonist |
| Solubility | Soluble in DMSO |
| Storage | Store at RT |
| IUPAC Name | 2-methyl-5-(6-phenylpyridazin-3-yl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole |
| InChI | InChI=1S/C17H20N4/c1-20-9-14-11-21(12-15(14)10-20)17-8-7-16(18-19-17)13-5-3-2-4-6-13/h2-8,14-15H,9-12H2,1H3 |
| InChIKey | GTMRUYCIJSNXGB-UHFFFAOYSA-N |
| SMILES | CN1CC2CN(CC2C1)C3=NN=C(C=C3)C4=CC=CC=C4 |
| Reference | 1: Toyohara J, Ishiwata K, Sakata M, Wu J, Nishiyama S, Tsukada H, Hashimoto K. |
