A-674563 hydrochloride

• CAT Number: I005867
• Molecular Formula: C22H23ClN4O
• Molecular Weight: 394.90
• Purity: ≥95%
• Target: Akt1
• Solubility: DMSO: ≥ 30mg/mL
• Storage: Store at -20°C
• IC50: 14nm

A-674563 hydrochloride (Cat No.: I005867) is a potent and selective inhibitor of AKT1 (protein kinase B), exhibiting anticancer potential by targeting the PI3K/AKT signaling pathway. It shows preferential inhibition of AKT1 over AKT2 and AKT3, making it valuable for dissecting isoform-specific roles in cancer cell survival, growth, and metabolism. A-674563 hydrochloride also demonstrates moderate CDK2 inhibition, contributing to its antiproliferative effects. This compound is widely used in cancer research for understanding AKT-mediated signaling and exploring targeted therapeutic strategies in oncology.

Reference

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[2]. Zhu QS, et al. Soft tissue sarcoma cells are highly sensitive to AKT blockade: a role for p53-independent up-regulation of GADD45 alpha. Cancer Res, 2008, 68(8), 2895-2903. 


[3]. Tatsuya Okuzumi, et al. Synthesis and evaluation of indazole based analog sensitive Akt inhibitors. Mol Biosyst, 2010, 6(8), 1389-1402.