A-674563

• CAT Number: I004050
• CAS Number: 552325-73-2
• Molecular Formula: C22H22N4O
• Molecular Weight: 358.41
• Purity: ≥95%
• Synonyms: (2S)-1-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxy-3-phenylpropan-2-amine
• Target: Akt
• Solubility: DMSO ≥70mg/mL Water ≥70mg/mL Ethanol ≥10mg/mL
• Storage: 3 years -20C powder
• IC50: 14 nM (Akt1)
• InChI: InChI=1S/C22H22N4O/c1-15-21-11-17(7-8-22(21)26-25-15)18-10-20(13-24-12-18)27-14-19(23)9-16-5-3-2-4-6-16/h2-8,10-13,19H,9,14,23H2,1H3,(H,25,26)/t19-/m0/s1
• InChIKey: BPNUQXPIQBZCMR-IBGZPJMESA-N
• SMILES: CC1=NNC(C1=C2)=CC=C2C3=CN=CC(OC[C@@H](N)CC4=CC=CC=C4)=C3

A-674563(CAT: I004050) is a potent and selective Akt1 inhibitor with an IC₅₀ of 14 nM, effectively targeting the Akt1 kinase involved in cell survival, proliferation, and metabolism. It also exhibits inhibitory activity against protein kinase A (PKA) and cyclin-dependent kinase 2 (CDK2) with IC₅₀ values of 16 nM and 46 nM, respectively. This multi-kinase inhibition profile makes A-674563 a valuable compound in oncology research, particularly for studying the PI3K/Akt signaling pathway in cancer progression. It serves as a promising tool for developing targeted therapies aimed at disrupting aberrant cell signaling in various cancers.