For research use only. Not for therapeutic Use.
A-796260 (Item No. <span class=/itemid/>11606</span>) is a synthetic cannabinoid (CB) that shows high selectivity for the CB<sub>2</sub> receptor (K<sub>i</sub> = 0.77 nM) over the CB<sub>1</sub> receptor (K<sub>i</sub> = 2,100 nM). It also shows efficacy <em>in vivo</em> in models of inflammatory, post-operative, neuropathic, and osteoarthritic pain, activities which are selectively blocked by CB<sub>2</sub> receptor-selective antagonists. A-796260 degradant is an impurity that may be produced in the synthesis of A-796260. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
| Catalog Number | R065586 |
| CAS Number | 1616469-10-3 |
| Synonyms | LTI-258 Degradant |
| Molecular Formula | C22H30N2O2 |
| Purity | ≥95% |
| Storage | -20°C |
| InChI | InChI=1S/C22H30N2O2/c1-17(2)22(3,4)15-21(25)19-16-24(20-8-6-5-7-18(19)20)10-9-23-11-13-26-14-12-23/h5-8,16H,1,9-15H2,2-4H3 |
| InChIKey | LORODOQLOVWDSW-UHFFFAOYSA-N |
| SMILES | O=C(CC(C)(C)C(C)=C)C1=CN(CCN2CCOCC2)C3=C1C=CC=C3 |
| Reference | 1.Poso, A. and Huffman, J.W. Targeting the cannabinoid CB2 receptor: Modelling and structural determinants of CB2 selective ligands. British Journal of Pharmacology 153(2), 335-346 (2008). |
