A-85380 HCl

• CAT Number: I000325
• CAS Number: 174740-86-4
• Molecular Formula: C9H14Cl2N2O
• Molecular Weight: 237.12
• Purity: ≥95%
• Synonyms: A-85380; A 85380; A85380; A-85380 dihydrochloride;3-[(2S)-azetidin-2-ylmethoxy]pyridine dihydrochloride
• Target: nicotinic acetylcholine receptor agonist
• Solubility: Soluble in DMSO
• Storage: 0 - 4°Cfor short term (days to weeks), or -20 °C for long term (months).
• IUPAC Name: 3-[[(2S)-azetidin-2-yl]methoxy]pyridine;dihydrochloride
• InChI: InChI=1S/C9H12N2O.2ClH/c1-2-9(6-10-4-1)12-7-8-3-5-11-8;;/h1-2,4,6,8,11H,3,5,7H2;2*1H/t8-;;/m0../s1
• InChIKey: GVEVDINKRFDXFP-JZGIKJSDSA-N
• SMILES: C1CN[C@@H]1COC2=CN=CC=C2.Cl.Cl

A-85380 HCl（Cat No.:I000325）is a selective agonist of the α4β2 nicotinic acetylcholine receptor, a subtype involved in cognitive functions and nicotine addiction. By selectively activating these receptors, A-85380 HCl has been studied for its potential in treating disorders such as Alzheimer’s disease, schizophrenia, and other cognitive impairments. It is also explored for its effects on nicotine addiction and withdrawal symptoms. Preclinical research has shown that A-85380 can enhance memory and attention, making it a promising candidate for cognitive enhancement. Further studies are needed to assess its safety, efficacy, and potential therapeutic applications in humans.

Reference

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