A-867744

• CAT Number: I000063
• CAS Number: 1000279-69-5
• Molecular Formula: C20H19ClN2O3S
• Molecular Weight: 402.89
• Purity: ≥95%
• Synonyms: 4-[5-(4-chlorophenyl)-2-methyl-3-propanoylpyrrol-1-yl]benzenesulfonamide
• Target: Neuronal Signaling
• Solubility: in DMSO > 10 mM
• Storage: Store at -20°C
• IC50: ~ 1 uM
• InChI: InChI=1S/C20H19ClN2O3S/c1-3-20(24)18-12-19(14-4-6-15(21)7-5-14)23(13(18)2)16-8-10-17(11-9-16)27(22,25)26/h4-12H,3H2,1-2H3,(H2,22,25,26)
• InChIKey: ABACVOXFUHDKNZ-UHFFFAOYSA-N
• SMILES: CCC(=O)C1=C(N(C(=C1)C2=CC=C(C=C2)Cl)C3=CC=C(C=C3)S(=O)(=O)N)C

A-867744（Cat No.:I000063） is a compound that acts as a positive allosteric modulator of α7 nicotinic acetylcholine receptors (nAChRs). It has been shown to have an IC50 value of 0.98 μM for human α7 receptors and 1.12 μM for rat α7 receptors, in Xenopus laevis oocytes. Notably, A-867744 does not display any activity at 5-HT3A, α3β4, or α4β2 nAChRs. These findings suggest that A-867744 may have potential therapeutic uses in conditions that involve dysfunction of α7 nAChRs, such as Alzheimer’s disease and schizophrenia.