For research use only. Not for therapeutic Use.
A-908292 is a potent and selective acetyl-CoA carboxylase 2 (ACC2) inhibitor, with an IC50 of 23 nM for human ACC2. A-908292 can be used for the research of fatty acid metabolism[1][2]. A-908292 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
A-908292 (30 mg/kg; p.o.; twice a day for 2 weeks) reduces serum glucose and triglyceride levels in ob/ob mice[2].
A-908292 (15 mg/kg; p.o.; twice a day for 4 days) markedly reduces plasma triglyceride levels in ACC2 knockout mice[3].
A-908292 (30-100 mg/kg; p.o.; twice a day for 3 days) stimulates the PPAR-α-dependent signaling pathway in rats[2].
| Catalog Number | I043672 |
| CAS Number | 903886-95-3 |
| Synonyms | methyl N-[(2S)-4-[2-(4-propan-2-yloxyphenoxy)-1,3-thiazol-5-yl]but-3-yn-2-yl]carbamate |
| Molecular Formula | C18H20N2O4S |
| Purity | ≥95% |
| InChI | InChI=1S/C18H20N2O4S/c1-12(2)23-14-6-8-15(9-7-14)24-18-19-11-16(25-18)10-5-13(3)20-17(21)22-4/h6-9,11-13H,1-4H3,(H,20,21)/t13-/m0/s1 |
| InChIKey | OLMPAYQFDVALIH-ZDUSSCGKSA-N |
| SMILES | CC(C)OC1=CC=C(C=C1)OC2=NC=C(S2)C#CC(C)NC(=O)OC |
| Reference | [1]. Nishiura Y, et, al. Discovery of a novel olefin derivative as a highly potent and selective acetyl-CoA carboxylase 2 inhibitor with in vivo efficacy. Bioorg Med Chem Lett. 2018 Aug 1;28(14):2498-2503. [2]. Waring JF, et, al. Gene expression analysis in rats treated with experimental acetyl-coenzyme A carboxylase inhibitors suggests interactions with the peroxisome proliferator-activated receptor alpha pathway. J Pharmacol Exp Ther. 2008 Feb;324(2):507-16. [3]. Takagi H, et, al. A Novel Acetyl-CoA Carboxylase 2 Selective Inhibitor Improves Whole-Body Insulin Resistance and Hyperglycemia in Diabetic Mice through Target-Dependent Pathways. J Pharmacol Exp Ther. 2020 Mar;372(3):256-263. |
