A 943931 dihydrochloride

• CAT Number: I010820
• CAS Number: 1227675-50-4
• Molecular Formula: C17H21N5.2HCl
• Molecular Weight: 368.31
• Purity: ≥95%
• Synonyms: 4-((3R)-3-amino-pyrrolidin-1-yl)-6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-d]pyrimidin-2-ylamine
• Target: Histamine Receptor
• Solubility: Soluble to 100 mM in water and to 100 mM in DMSO
• Storage: Store at +4C
• IUPAC Name: 6-[(3R)-3-aminopyrrolidin-1-yl]-3,5-diazatricyclo[9.4.0.02,7]pentadeca-1(15),2(7),3,5,11,13-hexaen-4-amine;dihydrochloride
• InChI: InChI=1S/C17H21N5.2ClH/c18-12-8-9-22(10-12)16-14-7-3-5-11-4-1-2-6-13(11)15(14)20-17(19)21-16;;/h1-2,4,6,12H,3,5,7-10,18H2,(H2,19,20,21);2*1H/t12-;;/m1../s1
• InChIKey: ISYUFRNZHUOGLA-CURYUGHLSA-N
• SMILES: C1CC2=CC=CC=C2C3=C(C1)C(=NC(=N3)N)N4CC[C@H](C4)N.Cl.Cl

A 943931 Dihydrochloride(CAT: I010820) is a potent and selective antagonist of the histamine H₄ receptor, with pK₁ values of 7.15 and 8.12 for human and rat receptors, respectively. By targeting the H₄ receptor, it effectively modulates immune cell recruitment and inflammation, making it particularly valuable in inflammation and immunology research. This compound has demonstrated efficacy in preclinical models, including peritonitis, inflammatory pain, and neuropathic pain, highlighting its potential in studying inflammatory mechanisms and therapeutic interventions. A 943931 Dihydrochloride is an essential tool for exploring H₄ receptor biology and developing treatments for inflammatory and pain-related conditions.