For research use only. Not for therapeutic Use.
Potent and selective histamine H4 receptor antagonist
| Catalog Number | I047584 |
| CAS Number | 1027330-97-7 |
| Molecular Formula | C17H21N5 |
| Purity | ≥95% |
| IUPAC Name | 6-[(3R)-3-aminopyrrolidin-1-yl]-3,5-diazatricyclo[9.4.0.02,7]pentadeca-1(15),2(7),3,5,11,13-hexaen-4-amine |
| InChI | InChI=1S/C17H21N5/c18-12-8-9-22(10-12)16-14-7-3-5-11-4-1-2-6-13(11)15(14)20-17(19)21-16/h1-2,4,6,12H,3,5,7-10,18H2,(H2,19,20,21)/t12-/m1/s1 |
| SMILES | C1CC2=CC=CC=C2C3=C(C1)C(=NC(=N3)N)N4CC[C@H](C4)N |
| Reference | MD Cowart et al. Rotationally constrained 2,4-diamino-5,6-disubstituted pyrimidines: a new class of histamine H4 receptor antagonists with improved druglikeness and in vivo efficacy in pain and inflammation models. J. Med. Chem. 2008, 51, 6547.
R Leurs et al. Molecular and biochemical pharmacology of the histamine H4 receptor. Br. J. Pharmacol. 2009, 157, 14.
RA Smits et al. Major advances in the development of histamine H4 receptor ligands. Drug Disc. Today. 2009, 14(15-16), 745. |
