For research use only. Not for therapeutic Use.
A1AT modulator 2 (compound 33) is a modulator of A1AT (α-1 antitrypsin) with an IC50 value of ＞1.0 μM and an EC50 value of ＜0.4 μM. A1AT modulator 2 can be used for the research of infection and inflammation[1].
| Catalog Number | I042659 |
| CAS Number | 2555004-05-0 |
| Synonyms | 4-[5-(4-fluorophenyl)-6-(oxan-4-yl)-1H-pyrrolo[2,3-f]indazol-7-yl]benzoic acid |
| Molecular Formula | C27H22FN3O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C27H22FN3O3/c28-20-5-7-21(8-6-20)31-24-13-19-15-29-30-23(19)14-22(24)25(26(31)17-9-11-34-12-10-17)16-1-3-18(4-2-16)27(32)33/h1-8,13-15,17H,9-12H2,(H,29,30)(H,32,33) |
| InChIKey | BEMKXFFRSZUYSK-UHFFFAOYSA-N |
| SMILES | C1COCCC1C2=C(C3=C(N2C4=CC=C(C=C4)F)C=C5C=NNC5=C3)C6=CC=C(C=C6)C(=O)O |
| Reference | [1]. Bandarage, Upul Keerthi, et al. Pyrrolo[2,3-f]indazole derivatives as modulators of α-1 antitrypsin and their preparation. US20200361939. 2020. |
